Radioiodine treatment of multinodular non-toxic goitre.

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Radioiodine treatment of multinodular non-toxic goitre.

OBJECTIVE To investigate the long term effect of radioactive iodine on thyroid function and size in patients with non-toxic multinodular goitre. DESIGN Consecutive patients with multinodular non-toxic goitre selected for radioactive iodine treatment and followed for a minimum of 12 months (median 48 months) after an intended dose of 3.7 MBq/g thyroid tissue corrected to a 100% uptake of iodin...

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Radioiodine treatment for non-toxic goitre

There is no ideal treatment for benign multinodular goitre. Besides surgery, which is recommended for large goitres or when malignancy cannot be excluded, the non-surgical treatment options are levothyroxine therapy and radioiodine ((131)I) therapy. Conventional (131)I therapy [without recombinant human thyroid-stimulating hormone (rhTSH)] has been used for more than a decade in symptomatic non...

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Takotsubo cardiomyopathy following radioiodine therapy for toxic multinodular goitre.

We report on a 73-year-old man with a toxic multinodular goitre, which was treated with radioiodine therapy (I-131) without pretreatment with an antithyroid drug. Four weeks later he presented with rapidly progressive dyspnoea and a significant increase in free thyroxin. The electrocardiogram showed ST -segment elevation, and echocardiography demonstrated apical akinesia and a left ventricular ...

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Serum TSH and the response to radioiodine treatment of toxic multinodular goitre.

A retrospective analysis of data from 73 consecutive patients with toxic multinodular goitre treated with iodine-131 (131I) during a 2-year period was performed to investigate if serum TSH at the time of 131I treatment influences the outcome. The dose of 131I was calculated according to a model compensating for thyroid size estimated by palpation and 24-h 131I uptake. Serum TSH was determined b...

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Nonsurgical treatment of multinodular nontoxic goitre.

Sporadic multinodular goitre is common in the UK, affecting up to 40,, of the population. Spontaneous reduction in goitre size is unlikely and steady growth at about 20",, per annum may be seen if untreated. Treatment is indicated for pressure symptoms on the trachea, assymmetrical increase in size suggesting underlying malignancy, a sudden increase in size due to colloid degeneration or haemor...

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ژورنال

عنوان ژورنال: BMJ

سال: 1993

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.307.6908.828